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Four girls at a prestigious private school discover that they can accomplish great things by putting their differences aside, and working together towards a common goal. Paige and Claire are the newest arrivals at Danforth Academy. Though fitting into such an exclusive environment is never easy, it isn't long before the two girls strike up a friendship with returning students Taylor and Abby. In no time, the group is inseparable. Not only is their alliance a great benefit to themselves, but when the students and faculty of Danforth Academy start to fall mysteriously ill, it proves essential in maintaining the reputation of the esteemed private school as well. Could the perpetrators be mean rich girls Riley and Mia? Perhaps Emily, the principal's eccentric daughter is to blame? Science teacher Professor Plume has access to the kind of chemicals that might make people sick, but what motive could he have for poisoning the student body? When Paige, Claire, Taylor, and Abby learn to focus on their similarities rather than their differences, they realize that there's no mystery they can't solve by using a little teamwork.