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In this western based on a novel by Zane Grey, Buck Duane (George O'Brien) is a cowboy who is forced to kill a man in an act of self-defense; the same man also took the life of Buck's father. However, the law isn't so sure Buck's motivations were pure, and Buck is forced to leave town one step ahead of the peace officers. Buck gets a chance to prove his good intentions when he helps protect a rancher who is being harassed by a gang of thugs, and also rescues his lady love, Ruth (Lucille Brown), from the same outlaws. However, Buck's brave actions do not come without retaliation -- and they also attract the attention of Lola (Myrna Loy), one of the hombre's molls. The Last Of The Duanes was filmed before in 1924 (with Tom Mix in the lead), and the story would hit the screen again in 1941, starring George Montgomery.