AllMovie

When a powerful new drug opens the gateway for an inter-dimensional invasion, the only two people on the planet capable of saving mankind are a pair of dubious amateur exorcists. Adapted from author David Wong's cult novel of the same name, Don Coscarelli's John Dies at the End opens to find a revolutionary drug called "Soy Sauce" allowing users to transcend time and space. But it can also have one very disturbing side effect; some people who take Soy Sauce experience a shocking physical transformation. When the world faces a threat that seems beyond human comprehension, only college dropouts John (Rob Mayes) and David (Chase Williamson) have the power to drive the mysterious invaders back. But there's no guarantee that they'll succeed. Paul Giamatti, Clancy Brown, and Doug Jones co-star in this outlandish horror comedy from the director of Bubba Ho-Tep.