John Dies at the End on AllMovie

When a powerful new street drug opens the gateway for an inter-dimensional invasion, the only two people on the planet capable of saving mankind are a pair of clueless college dropouts. Adapted from author David Wong's cult novel of the same name, Don Coscarelli's Joe Dies at the End finds humanity getting hooked on Soy Sauce, a revolutionary drug that allows the user to transcend time and space. But it can also have one very disturbing side effect; some people who take Soy Sauce experience a shocking physical transformation. When the world faces a threat that seems beyond human comprehension, only jobless slackers John and David have the power to drive the mysterious invaders back. But even then there's no guarantee that they'll truly succeed. (Paul Giamatti, Clancy Brown, and Doug Jones star in this outlandish horror comedy from the director of Bubba Ho-Tep.