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This sequel attempts to ape the inventive blend of horror, comedy, and crime melodrama of its predecessor, with some creative direction by actor Sam Spiegel, a protégé of Sam Raimi. Buck (Robert Patrick) is a former bank robber who's being watched closely by Sheriff Lawson (Bo Hopkins). Lawson's suspicions are well-founded, because Buck is indeed planning a multimillion-dollar bank heist in Mexico, to be aided by prison escapee Luther (Duane Whitaker), rodeo star C.W. (Muse Watson), dog trainer Jesus (Raymond Cruz) and security guard Ray Bob (Brett Harrelson). While on his way to meet up with the gang, Luther encounters bat-related car trouble near the Titty Twister, a dive bar featured in the first film. Offered a lift by Razor Eddie (Danny Trejo), Luther ends up with a pair of fangs in his neck. When he finally meets up with his cronies, Luther turns Jesus into a fellow vampire, unbeknownst to the rest of the gang, who proceed with their caper plans accompanied by two cohorts now more interested in blood than cash. The film was followed by a prequel, From Dusk Till Dawn 3: The Hangman's Daughter (2000).