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Cissy (Kathy Garver) has been assigned to babysit the twins while Uncle Bill (Brian Keith) is in Hong Kong on business and Mr. French (Sebastian Cabot) is likewise occupied elsewhere. But when Cissy has a chance to go to a concert, she prevails upon her friend Sharon (Sherry Alberoni) to look after the kids. This sets off a chain reaction of hilarious havoc: Sharon comes down with the measles, Sharon's mother (Doris Singleton) assumes the babysitting duties before she too must leave, and the twins end up in the care of Sharon's father (Walter Sande). and his poker-playing buddies. Somehow this messes straightens itself out in a roundabout fashion that also solves Bill's problems with a nagging toothache!