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Born in Boston, Lou Breslow was raised in California, where he received his first training in the motion picture industry as a film extra. At various junctures, Breslow was a cameraman and story consultant before graduating to screenwriting and directing. With a predilection for comedy, Breslow made uncredited contributions to the Marx Bros. films Horse Feathers (1932) and Duck Soup (1933) and directed several 2-reelers, including the early Three Stooges opus Punch Drunks (1934). He spent many years in the screenwriting pool at 20th Century-Fox, writing for everyone from Betty Grable to Mr. Moto (Peter Lorre). He also wrote scripts for funnymen Bob Hope and Red Skelton. Keeping his hand in directing into the 1950s, Lou Breslow helmed the delightful comedy-fantasy You Never Can Tell (1951) and also contributed his services as scripter and story consultant for dozens of TV anthologies.