Academy of Motion Picture Arts and Sciences
| Nominated |
Best Actress The Savages |
2007 |
| Nominated |
Best Actress You Can Count On Me |
2000 |
| Nominated |
Best Supporting Actress Kinsey |
2004 |
Academy of Television Arts and Sciences
| Nominated |
Outstanding Lead Actress in a Comedy Series The Big C [TV Series] |
2011 |
| Won |
Outstanding Lead Actress in a Miniseries or a Movie John Adams |
2008 |
Broadcast Film Critics Association
| Nominated |
Best Supporting Actress Kinsey |
2004 |
Chicago Film Critics Association
| Nominated |
Best Actress The Savages |
2007 |
Detroit Film Critics Society
| Nominated |
Best Actress The Savages |
2007 |
Golden Satellite Award
| Nominated |
Best Performance by an Actress in a Motion Picture - Drama The Savages |
2007 |
Hollywood Foreign Press Association
| Won |
Best Performance by an Actress in a Miniseries or Motion Picture Made for Television John Adams |
2008 |
| Nominated |
Best Performance by an Actress in a Motion Picture - Drama You Can Count On Me |
2000 |
| Nominated |
Best Performance by an Actress in a Motion Picture - Musical or Comedy The Squid and the Whale |
2005 |
| Nominated |
Best Performance by an Actress in a Supporting Role in a Motion Picture Kinsey |
2004 |
| Won |
Best Performance by an Actress in a Television Series - Musical or Comedy The Big C [TV Series] |
2010 |
Independent Spirit Awards
| Nominated |
Best Actress The Squid and the Whale |
2005 |
| Nominated |
Best Actress You Can Count On Me |
2000 |
London Film Critics Association
| Nominated |
Best Actress Kinsey |
2005 |
National Board of Review
| Won |
Best Supporting Actress Kinsey |
2004 |
National Society of Film Critics
| Won |
Best Actress You Can Count On Me |
2000 |
| Won |
Best Supporting Actress (Runner-up) Kinsey |
2004 |
New York Film Critics Circle
| Won |
Best Actress You Can Count On Me |
2000 |
Screen Actors Guild
| Nominated |
Best Actress You Can Count On Me |
2000 |
| Won |
Best Performance by an Actress in a Miniseries or Motion Picture Made for Television John Adams |
2008 |
| Nominated |
Best Supporting Actress Kinsey |
2004 |
Toronto Film Critics Association
| Nominated |
Best Actress The Squid and the Whale |
2005 |
| Won |
Best Actress You Can Count On Me |
2000 |
| Won |
Best Supporting Actress [Runner-up] The House of Mirth |
2001 |
