- Grew up on the campus of Phillips Exeter Academy, where his father taught mathematics.
- Sang with the glee club at Amherst College.
- Turned to writing after his career as a singer-songwriter in Los Angeles, where he self-produced four pop albums, failed to take off.
- Wrote a 1995 advice book titled 187 Men to Avoid: A Guide for the Romantically Frustrated Woman under the pseudonym Danielle Brown.
- Released his first novel, the techno-thriller Digital Fortress, in 1998.
- Can be seen in the audience of an Aerosmith concert in 2005 comedy Be Cool.
- Named to TIME magazine's list of the 100 most influential people in 2005.
- His Da Vinci Code sequel The Lost Symbol sold more than 1 million copies in hardcover and e-book versions during its first day of release in 2009.
- Has claimed he uses gravity boots when trying to work out difficult plot developments for his novels.
- Wife, Blythe, is an art historian who often helps with the research for his novels.