- Was a McDonald's and Parade Magazine All-American in high school.
- In 2003, led Syracuse to its first national basketball championship in his only season at the school; was named NCAA tournament MVP.
- Was the third pick in the 2003 NBA Draft by the Denver Nuggets.
- Played for the U.S. Olympic basketball team, winnning a bronze medal in 2004 and gold in 2008, 2012 and 2016; after the 2016 Olympics in Rio, he announced he was retiring from the U.S. national team.
- Has done charity work for children's organizations, tsunami relief and Hurricane Katrina victims.
- Donated $3 million to Syracuse University for new practice facilities, which the university named the Carmelo K. Anthony Center.
- Founded a production company, Krossover Entertainment.
- Married entertainer La La Vazquez in 2010; the ceremony was filmed for the reality series La La's Full Court Wedding.
- In 2011, traded from the Denver Nuggets to his hometown New York Knicks, who play at Madison Square Garden, the arena where he scored his first collegiate basket.
- Set a New York Knicks and Madison Square Garden record for points in a game with 62 points on Jan. 24, 2014.