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Radiant New York City vampires Goody (Alicia Silverstone) and Stacy (Krysten Ritter) find their immortality in question after they learn that true love endures in the realm of the undead. Meanwhile, Russian bloodsucker Vadim (Justin Kirk) prowls the streets in search of the next big thrill, Dr. Van Helsing (Wallace Shawn) seeks to exterminate the creatures of the night, and young Joey Van Helsing (Dan Stevens) develops an unusual fixation on Stacy. As ravenous vampire Cisserus (Sigourney Weaver) presides over her dark dynasty with the help of her loyal assistant Ivan (Todd Barry), oddball Renfield (Zak Orth) strives to impress Stacy and Goody by any means necessary. Amidst all of the bloodshed and intrigue, nefarious vampire Vlad (Malcolm McDowell) works to perfect his knitting skills.