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Two Wise Maids was an attempt by Republic Pictures to recapture the magic of MGM's Marie Dressler-Polly Moran vehicles. Dressler, alas, had died, but Republic was able to secure the services of Moran, teaming the raucous comedienne with the magnificent Alison Skipworth. The two leading ladies are cast as Prudence and Agatha, a pair of old-fashioned schoolteachers in an old-fashioned small town. Disdaining the wimpy theories of "progressive" education, Prudence and Agatha stick to the reliable "Three R's," often teaching to the tune of a hickory stick. Though ridiculed for their so-called outmoded methods, the heroines manage to turn out quite a few prize students, earning the undying gratitude of the local citizenry. The obligatory romantic subplot involves school principal Bruce (Donald Cook) and substitute teacher Ellen (Hope Manning, later billed as Irene Manning).