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The Larry Sanders Show is celebrating its eighth anniversary, and guests k.d. lang, Pat O'Brien, Rosie O'Donnell, Mandy Patinkin, and Noah Wyle are booked for the big show. It seems that Murphy's Law is in full effect for the anniversary show, however, and in addition to O'Donnell's limo failing to arrive, it's revealed that lang and Hank (Jeffrey Tambor) have a background as feuding neighbors, while Patinkin and Wyle can't stop arguing over who has a better TV series. As if those factors weren't enough to make the anniversary show a stressful occasion, it seems as if Larry (Garry Shandling) has forgotten to take his usual bathroom break before the show.