The Flintstones : Fred Goes Ape (1966)
Directed by William Hanna / Joseph Barbera
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Synopsis by Hal Erickson
Fred can't stop sneezing, so he goes to the doctor for some allergy pills. The prescription gets mixed up with another package of pills which, when taken, transform Fred into an ape! Only Barney witnesses this metamorphosis, and naturally he can't convince anyone what is happening...until a fateful family outing at the Bedrock Zoo.