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This Bowery drama features former D.W. Griffith actor Henry Walthall as Norman Strong, who runs a mission in a rough area of New York and is known as the "Bowery Bishop." One of the neighborhood girls, Venitia Rigola (Edith Roberts), is betrayed by lawyer Philip Foster (George Fisher), and she has a baby. Tim Brady (Lee Shumway), who loves Venitia, accuses Strong of being the father. Strong, who won't point his finger at the guilty party, refuses to deny the accusation, and Brady works up a mob into a frenzy. The mob wrecks the mission and drives Strong out of the Bowery. Eventually, Strong returns, but he is shot during a fight with a gang. He recovers from his wounds, and with the help of someone by the name of Mr. Kindly (Norval MacGregor), he is cleared of any wrongdoing. Foster finally does right by Venitia and marries her.