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While Metropolis gears up to honor its most popular "citizen" during Superman Week, gangster Si Horten (Herburt Vigran) tries to figure out a way to rid the town of the Man of Steel. Taking reporter Jimmy Olsen (Jack Larson) into his confidence, Horten gives Jimmy a milkshake laced with truth serum, whereupon the boy reveals the location of some hidden Kryptonite--the only substance that can render Superman helpless. Meanwhile, the ever-suspicious Lois Lane (Noel Neill) eagerly anticipates the awkward situation awaiting Clark Kent (George Reeves), who has been assigned to interview Superman on TV.