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Bizarro #1, the weird Superman doppelganger from Bizarroworld, uses his duplicator ray to create Bizarro versions of Wonder Woman, Firestorm and Cyborg. These "opposite clones" are then called upon to protect Bizarroworld from its many enemies. Unfortunately, the prankish Mr. Mxyzptlk plans to harness the powers of the three Bizarro superheroes in order to wreak havoc upon the earth, in an endless series of nasty pranks and practical jokes specially designed to drive everyone as crazy as HE is!