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Sex and Bullets stars Judd Nelson and Seymour Cassel as a pair of hitmen who are on the run from a powerful mobster after they whack one of the mobster's sons. The two go their separate ways in order to hide more effectively, but each ends up being involved in a bizarre adventure. Max (Nelson) ends up picking up an unstable woman by pretending to be a sex therapist. Eddie (Cassel) ends up losing the corpse.