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While 34-year-old "supermom" Margo Dalton (Juile Warner) is being treated for uncontrollable muscle spasms, her daughter Stella (Ellie Fanning) runs amok throughout the clinic. The doctors are unable to find the reason for Margo's bizarre affliction, mainly because (surprise!) she has been lying to her husband about her medical condition. As for House (Hugh Laurie), he and Stacy (Sela Ward) have come to an "understanding" which permits him to wallow in misery as only he can, while Wilson (Robert Sean Leonard), who has had plenty of romantic misadventures of his own, tries to help House pick up the pieces. And after her run-in with AIDs patient in the earlier episode "Hunting", Cameron (Jennifer Morrison) is worried that she is now HIV-positive.