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Journalist Helmut Dantine, having spent eight years as a convict on Devil's Island, devotes his energies to exposing the horrible conditions at the notorious penal colony. The governor of French Guinea is sympathetic but helpless, since the Devil's Island overseer (William Talman) has technically committed no crime. Investigating the situation, Dantine learns that Talman is the mastermind of a gold-smuggling operation run by the owners of a nearby plantation. The reporter catches Talman in the act, breaks up the operation, and claims the governor's daughter (Donna Martell) for the fadeout clinch. Hell on Devil's Island is one of a group of inexpensive second features produced by 20th Century-Fox's Regal Films division in the late 1950s.