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Recovering from her near-death experience, Meredith (Ellen Pompeo) is convinced that her outlook on life has completely changed. More and more candidates are vying for the chief-of-surgery position soon to be vacated by Webber (James Pickens Jr.), among them handsome doctor Colin Marlow (Roger Rees), whose arrival has a strange effect on Cristina (Sandra Oh). Derek (Patrick Dempsey) finds himself treating an old friend (Shohreh Aghashloo) whose tumor may well be inoperable. Still trying to cope with the loss of Denny Duquette, Izzie (Katherine Heigl) is profoundly moved by WW2 vet Scofield (James Gammon),who has come to Seattle Grace to remove a bullet that has been lodged in his body for over sixty years. And Alex (Justin Chambers) prepares the first of several operations on the severely injured "Jane Doe" (Elizabeth Reaser). This is the episode in which George (T.R. Knight) begins questioning the wisdom of his marriage to Callie--culminating in a drunken misadventure with another female staffer!