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In the second episode of a three-part story arc, Meredith (Ellen Pompeo) has fallen in the water at the scene of a horrendous ferryboat disaster, and is still among the missing. Izzie (Katherine Heigl) takes medical instructions by phone as she performs emergency cranial surgery on a victim trapped between two cars. George (T.R Knight) tells a mother that her son has been found safe so she would agree to undergo surgery--and now must conduct a frantic search for the boy. And while trying to mollify the victims' families, Alex forms an unusual bond with an unidentified pregnant woman (Elizabeth Reaser) who has sustained mulitple injuries. With all this going on, Cristina and Burke still find time to announce their upcoming wedding--only to start quarrelling the moment the words are out of their mouths.