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Wildly popular TV talk show host Bobby Bishop (Vincent Gallo) has a nervous breakdown during an on-camera interview with a pop starlet, with whom he makes a rather crude observation and offer. This lapse of taste sets off a series of scandals in his off-camera life, which his beleaguered agent (Jeffrey Tambor) is helpless to stop. Desperate for love, Bobby rushes to New York City to find his former girlfriend, Lily (Courteney Cox), who doesn't even like his show, and neither does her cross-dressing boyfriend (Tate Donovan). Can true love straighten out the messes that are these folks' lives?