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A writer runs an obstacle course of neuroses as he prepares to debut an important new work in this comedy drama. Nicky Rogan (Michael Keaton) is a successful playwright who, after a series of hit comedies, is about to debut a deeply personal drama, and is more than a little nervous about how it will be received. Rogan has learned that notoriously tough critic Steven Schwimmer (Robert Downey Jr.) will be reviewing the opening night performance; a bad notice from Schwimmer sent Nicky's good friend and fellow writer Elliott (Griffin Dunne) into an emotional tailspin from which he's yet to recover. Rogan also has reason to believe that Peter Redmond (Harris Yulin), the play's leading man, may have a serious health problem that could sideline the show. Rogan is being dogged by personal anxieties as well -- his wife, Lillian (Catherine O'Hara), is leaving him, he's having an affair with Joanne (Bebe Neuwirth), who is bankrolling the show, his father (Tom Aldredge) is in failing health, and the life-long Boston Red Sox fan is panicking as his heroes are being trounced by the New York Mets in game six of the World Series. Game Six was the first original screenplay from noted novelist and playwright Don DeLillo; the film premiered at the 2005 Sundance Film Festival.