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Another crisis looms at the Crane household when Eddie the dog sires a litter of puppies. Solemnly, Frasier (Kelsey Grammer) and Niles (David Hyde Pierce) declare that it is high time Eddie was neutered. When Martin (John Mahoney) balks at taking his pet to the vet, Frasier grabs the bull (or the dog) by the horns and makes the trip himself. Unfortunately, Eddie catches on to what's in store for him and runs out of the vet's office in a panic, leading Frasier and Niles on a frantic search throughout the length and breadth of Seattle.