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The scene is San Francisco, where a diabolically crafty serial killer is preying on newlywed couples, killing the groom before the bride and then removing both wedding rings. Assigned to track down this maniac is homicide inspector Lindsay Boxer (Tracy Pollan), who, despite the usual quota of false clues and red herrings, seems more than prepared for the biggest challenge of her career. But Lindsay is not prepared for facing her own mortality: She has been diagnosed with a blood disease that nearly always proves fatal and may not live long enough to bring the honeymoon killer to justice. Based on a novel by James Patterson (as indicated by the film's "official" title), First to Die debuted February 23, 2003, on NBC.