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A doctor's past comes back to haunt him in an unexpected way in this modern variation on the classic tale of Faust. Dr. Fausto (Miguel Angel Sola) is a respected oncologist whose career has practically taken over his life; he has no wife or children, and he's barely aware of the fact his beautiful assistant Julia (Najwa Nimri) is obviously in love with him. One day, Fausto finds himself so overwhelmed with his wildly stressful career that be begins pondering suicide as he waits for a train, only to be interrupted by Julia, who brings him the briefcase he left at his office. After boarding his train, the distraught Faust encounters Santos Vella (Eduard Fernandez), who introduces himself as one of Fausto's former patients; after Fausto removed his stomach and informed him that he had but three months to live, Vella opted to stop seeing doctors and ignore their advice -- and he says he's been feeling fine ever since. Despite Vella's contemptuous attitude towards modern medicine, he is both friendly and grateful to Fausto, and insists on giving the doctor a ride after a taxi breakdown leaves Fausto stranded. From then on, Fausto finds he can't get rid of his new friend, no matter how hard he tries -- everywhere he goes, Vella is close behind, and when Faust declares that he needs female companionship instead, Vella arranges for Fausto to spend the evening with Marta (Irene Montala), a prostitute who proves to be similarly unavoidable. Fausto 5.0 was the first motion picture directed and produced by members of La Fura, an acclaimed Spanish theater troupe.