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Don Cheadle makes his first series appearance as Paul Nathan, an overaged med student who chose to enter school only after being diagnosed with Parkinson's disease. During his first shift, Nathan plunges in to help the other staffers treat the victims of a Halloween party fire -- whereupon his colleagues notice that he doesn't react all that well to intense pressure. In other developments, Corday (Alex Kingston) and Romano (Paul McCrane) battle over a patient who may be facing an amputation; despite her recent erratic behavior, Weaver (Laura Innes) tries to save a baby who was all but killed in a home birth gone awry; and the romance between Chuny (Laura Ceron) and Kovac (Goran Visnjic) is sabotaged by his insatiable addiction to sex.