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Freshly escaped from Manticore, Max (Jessica Alba) touches base with her inner-city pal Original Cindy (Valarie Rae Miller), who now knows that crusading journalist Logan (Michael Weatherly) is leading the "Eyes Only" resistance movement against the corrupt power structure. With Cindy's help, Max takes several of Manticore's youthful transgens under her wing, determined to protect them from the Manticore minions. Meanwhile, the sinister Ames White (Martin Cummins) intends to "correct" the mutant mistakes made by Manticore's Madame X -- through the simple expedient of killing them all, beginning with Max.