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Eleven of the 12 jurors in a murder trial are all for convicting the defendant. The 12th juror is a holdout -- and worse, he is an awful man who has incurred the hatred of the other 11. Thus, there is no shortage of suspects when the holdout is found dead in the jury room. Elsewhere in town, a woman whose sister disappeared four years ago claims that her brother-in-law killed her sister; alas, the woman also insists that the killer burned the body and disposed of the ashes in a river, leaving CSI with literally nothing to work with.