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The effects of schizophrenia reverberate through three generations of educated Indian women when a woman is diagnosed with the psychotic disorder and those around her, including her westernized daughter, struggle to maintain normal lives. As Azumi 2 gets underway, remaining assassins Azumi and Nagara set out in pursuit of their final target - the notorious Masayuki Sanada. But Sanada is fully prepared for the confrontation; he's hired the dreaded Koga Ninja Clan to dispense with Azumi, and they won't stop until their mission has been completed. The Koga Ninja Clan aren't the only foes that Azumi has to worry about either, because Kiyomasa's failed retainer Kanbei is out for blood as well. With enemies closing in from all sides, things are beginning to look decidedly grim for the assassin forced to choose between love and duty.