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A pair of super-sized snakes have escaped from a top-secret research laboratory, destroying the European countryside and consuming everything in their path as the terror continues in this made-for-cable installment of the slithering Anaconda series. In a secret government compound deep underground, brilliant research scientist Amanda (Crystal Allen) studies a pair of enormous snakes for a series of experiments funded by wealthy recluse Murdoch (John Rhys-Davies). When Murdoch crosses the line, disaster strikes and his two most prized snakes quickly find their way to the surface. Hungry, angry, and with nothing to prevent them from consuming everything and everyone who happens to cross their paths, the two snakes terrorize the locals until ruthless mercenary Hammett (David Hasselhoff) appears determined to put them on the endangered species list. Now, Hammett will team with Amanda on a mission to stop the slaughter before the snakes reach the city. But one of the snakes is pregnant with an entire litter of slithering giants, a fact which could bump mankind one notch down on the food chain should the baby snakes manage to escape and reproduce. With time running out before the snakes reach the city and a new breed emerges, Hammett and Amanda attempt to put their differences aside long enough to dispose of these colossal serpents once and for all.