Hotel Room is a made-for-cable anthology, featuring three separate stories that are all set in the same New York hotel room over different years. Set in 1992, the first, "Getting Rid of Robert," features three girlfriends who devise a plan to help Sasha dump her sleazy movie executive boyfriend. The second, set in 1969, is called "Tricks" and is about a dull, junkie prostitute Darlene, her client Moe and the sudden re-appearance of Moe's friend Lou. "Blackout," the last story, is set in 1936 and is about a young husband who is attempting to accept the madness of his gorgeous wife.