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Viola Dana plays both of the title characters in Rayart's Two Sisters. One of the heroines is a daring female bandit, while the other is her sweet, virtuous sister. A murder is committed, and both girls fall under suspicion. With precisely no help from intrusive comedy-relief character Irving Bacon, hero Rex Lease sifts through the clues and solves the case. Based on a novel by Virginia Terhune Vandewater, Two Sisters features Boris Karloff as a dapper secondary crook named "Cecil." A silent film, it qualified as a "soundie" with the addition of a synchronized musical score.