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"The Adult Brain: To Think by Feeling" (Part 4) explores the relationship between reason and emotion. "We are not thinking machines," says Antonio Damasio of the University of Iowa. "We are feeling machines that think." But one man profiled was left unfeeling by a stroke ("It's as if I lost my best friend," says his wife) while another, an auto-accident victim with post-traumatic stress disorder, is overcome by terror ("It's not a memory," says Harvard's Roger K. Pitman, "it's a reexperiencing situation"). The hour also looks at neurological reasons for depression---"the ultimate isolation," says psychologist Lauren Slater.