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The Lady from Nowhere is manicurist Polly (Mary Astor) who is the wrong girl at the wrong place when a gangland murder occurs. Taking it on the lam, Polly is pursued by both the gangsters and the police. The cops could have taken a little time to put a tail on the suspected murderer, but why let logic get in the way of a good story? Equally illogical is the decision by the fugitive Polly to pose as a small-town heiress as a means of getting her hands on some getaway money. Since such a ploy could serve only to reveal her whereabouts to the villains, it's surprising that heroic newspaperman Earl (Charles Quigley) comes to Polly's rescue instead of chastising her with a "Geez, what a dummy!"