Bert Wheeler and Robert Woolsey star as Roy Banks and Dr. "Painless" Pennington, itinerant dentists in the Old West. Roy and Doc purchase a dentist's office from a crooked real-estate promoter (Richard Alexander), who neglects to tell our heroes that everyone in town is planning to head off via wagon train to the California Gold Rush. By the time they discover that they've set up shop in a ghost town, the boys have also uncovered evidence that the townsfolk are heading right into an Indian ambush. They quickly catch up with the wagon train, where Roy falls in love with cute schoolmarm Mary Blake (Dorothy Lee). Managing to convince the townsfolk that they're all about to be massacred, Roy and Doc are themselves accused of arranging the impending slaughter by Hank (Harry Woods) and Trigger (Ethan Laidlaw), the two greedy reprobates who'd cooked up the massacre in collaboration with the Indians. Escaping a lynch mob, the boys hide out at a nearby Indian reservation, where they discover that Hank is in cahoots with the Chief. Roy and Doc manage to make their way back to the wagon train, where they save the day by pelting the attacking Indians with chloroform-soaked sponges. Justifiably regarded as the worst of the Wheeler and Woolsey comedies, Silly Billes reaches its nadir when the two stars drunkenly attempt to extract a tooth from a billy goat!
by Hal Erickson synopsis