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Season six of NYPD Blue begins with a story arc designed to prepare viewers for the inevitable departure of series regular Jimmy Smits (Detective Bobby Simone). It all begins as Bobby's dentist asks the detective to check up on the dentist's daughter, whose boyfriend is a slimy drug dealer. When the boyfriend is stabbed, disreputable private eye Mike Roberts (Michael Harney), currently the bodyguard of the victim's father, asks the cops to give the case "special" handling -- much to the disgust of Bobby's partner, Andy Sipowicz (Dennis Franz), who despises Roberts. Elsewhere, a false-alarm rape investigated by Bobby's wife and co-worker, Diane Russell (Kim Delaney), turns out to be the real things; John Irvin (Bill Brochtrup), returning to the precinct after his business folds, strikes up a friendship with new PAA Dolores Mayo (Lola Glaudini); and, on a more ominous note, Bobby begins to exhibit signs of a potentially serious illness.