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Beautiful but impractical socialite Penelope Newbold (Carole Lombard) has convinced herself that "the perfect marriage" is an impossible concept. After all, she reasons, no one man could possess all the virtues required for an ideal husband. Thus, she divides her time between dependable, hard-working gynecologist Dr. Karl Bemis (Paul Lukas) and wastrelly playboy Bill Hanaway (Ricardo Cortez). Penelope wises up in a hurry when Bill turns up murdered in the bedroom of another woman, whereupon our heroine takes a crash course in nursing to prove worthy of the faithful Dr. Bemis. If Carole Lombard had continued starring in dreck like No One Man, chances are that she wouldn't have attained the legendary status she presently enjoys in the annals of movie history.