Dean Martin reprises his role as Matt Helm, famed secret agent who is part James Bond and part Rat Packer, in Murderer's Row. The film concerns the nefarious plan of arch-villain Julian Wall (Karl Malden) to take over the world by kidnapping Dr. Norman Solaris (Richard Eastham), who has invented a "helio-beam" -- a device that can harness the rays of the sun to destroy the earth. To insure his plans go smoothly, Wall has eliminated most of the ICE (Intelligence and Counter-Espionage) agents. But luckily for the world, super-agent Matt Helm, having escaped from being boiled to death in his own swimming pool, is hot on Wall's trail. Traveling to the Riviera, Helm meets Solaris's mod daughter Suzie (Ann-Margret) and they team up to rescue her father. Helm poses as a gunman on the run and Wall hires him. Wall becomes suspicious when Helm saves Suzie's life after she is threatened by one of Wall's goons, but Matt and Suzie escape from Wall and make their way to his island fortress, where they must find Solaris and disarm the "helio-beam" before Wall destroys Washington, D.C.
