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A sort of follow-up to the studio's earlier College Scandal, Paramount's Murder Goes to College once again combines homicide with higher learning. When the titular murder occurs, detective Hank Hyer (Lynne Overman) shows up to investigate, with vacationing reporter Sim Perkins (Roscoe Karns) tagging along. Both of our heroes run up against formidable opposition from a strangely secretive faculty, an openly hostile local constabulary, and sneering racketeer Strike Belno (Larry "Buster" Crabbe). Foremost among the suspects is Greta Barry (Astrid Allwyn), the ex-showgirl spouse of much-despised professor Tom Barry (Earl Foxe). Much of the suspense in Murder Goes to College arises from the possibility that the bibulous Sim Perkins won't remain sober long enough to solve the mystery.