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Lost in Hollywood tells the wacky tale of a down-and-out filmmaker who plots a scheme to snag clients from under his mob boss' nose in order to fund his dream project. Flunking out of various grunt movie jobs seemed to be the only thing that Mark Grossman excelled at. When the chance presents itself to work at a telemarketing firm, he jumps at the chance. Little does Mark know, the company is run by the mafia, whose company plan involves bribes in its day-to-day operations. Soon the film's unlucky hero begins a dangerous game of funneling clients' money into his own movie project with over-the-top hijinks to follow.