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Loose Cannons may be a wacky buddy-cop comedy, but it starts with a chilling premise. It seems that a film is discovered that depicts the final moments of Adolf Hitler's life. The climax features young German officer Von Metz, who is seen putting Hitler to death. Von Metz (Robert Prosky) is now running for chancellor of West Germany. If this film gets out, his political career is finished, so Von Metz has arranged for the murder of anyone who has seen the film. The killings have taken place in the Washington area and Mac (Gene Hackman) and Ellis (Dan Aykroyd) are sent to investigate the crimes. Mac is a middle-aged veteran of the force, a professional who gets things done. But Ellis is a different ball of wax. Suffering from a multiple personality disorder, he has spent two years in a Benedictine monastery to recover from his problems. But he is far from cured -- as Mac discovers, whenever Ellis is confronted by violence, he blacks out and begins to assume the characters of popular culture icons like Popeye, Captain Kirk, and the Road Runner.