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Two kids with nothing in common are brought together in a very unexpected way in this comedy. Nell (Samaire Armstrong) is a pretty but hopelessly geeky teenage girl who loves Shakespeare and wants little more than to study literature at Yale when she graduates from high school in a few months Woody (Kevin Zegers), who lives next door, is the quarterback on the school's football team, and seems like a sure bet to land a lucrative football scholarship despite the fact he isn't especially bright. Nell and Woody are not at all friendly and normally have nothing to say to one another, but one day during a class field trip to a historical museum, the two fall under the spell of an Incan icon and when they awake the next morning, Woody's mind is in Nell's body, and vice versa. Neither is comfortable with their sudden gender switch or having to assume the other's personalities, but they quickly realize that until they can find a way to reverse the spell, they have to work together if Nell is to go to Yale and Woody is to get his scholarship and move away from this loutish parents (Sharon Osborne and Maury Chaykin. Elton John was an executive producer on It's A Boy Girl Thing, and songs from his back catalog appear on the soundtrack.