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A storyline departure from Iczer 1 and Iczer Reborn, Iczerlion is about a group of elite warrior women called Iczerlions who wear sentient body armor. The women need to protect the earth from two roving demons bent on destruction but they need another member to join their squad in order to do it. They choose Nagisa, a high-school girl, to do the job, but Nagisa is reluctant, to say the least. Defeating the demons will be difficult, but convincing Nagisa could be even harder.