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Throwing himself into his work to get his mind off his birthday, House (Hugh Laurie) is intrigued when diagnosed schizophrenic Lucille Palmeiro (Stacy Edwards) has a pulmonary embolism at the unusually young age of 38. In fact, he's so intrigued that he breaks his own self-imposed rule and tries to talk to the woman at her home--where her 15-year-old son Luke (Aaron Himelstein) seems to know a lot more than he's saying. Elsewhere, Chase (Jesse Spencer) has serious issues with his past. This episode affords a rare opportunity to hear Hugh Laurie speak in his authentic British accent.