The professional roles and real lives of a diverse group of surgeons collide unexpectedly in this Golden Globe-winning ABC television drama. As an intern at prestigious Seattle Grace Hospital, Meredith Grey (Ellen Pompeo) tries hard to live up to the reputation of her legendary surgeon mother while hiding the fact that her mom now suffers from Alzheimer's disease. As if life weren't complicated enough, Meredith also falls for her boss, Derek Shepherd (Patrick Dempsey), a surgical resident recently relocated to Seattle from New York. Meredith's friend and rival Cristina Yang (Sandra Oh) finds herself in a similarly taboo romance with Preston Burke (Isaiah Washington), Derek's chief competition for the title of chief resident. As for Meredith and Cristina's fellow interns -- Isobel "Izzie" Stevens (Katherine Heigl), George O'Malley (T.R. Knight), and Alex Karev (Justin Chambers) -- they've got problems of their own. Izzie doesn't want to be judged for her underwear-model past; Alex is better at bedding the ladies than bedside manner; and George can't get any of the women around him to see him as anything but a cuddly friend. All five interns answer to the roar of senior resident Miranda Bailey (Chandra Wilson), affectionately known as "the Nazi." But even Dr. Bailey jumps to it when Chief of Surgery Richard Webber (James Pickens Jr.) is on the scene. Although it was a hit from the time of its mid-season launch -- in a plum post-Desperate Housewives time slot -- on March 27, 2005, Grey's Anatomy had sat on the shelf for a year before it saw the light of day. Creator and executive producer Shonda Rhimes received plenty of accolades for her color-blind casting, but it was Oh who earned an Emmy nod and a Golden Globe statuette for her work on the show's first season.
by Brian J. Dillard synopsis