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An unusually high death rate at Seattle Grace has aroused the superstitious instincts of the hospital staff. In particular, Izzie (Katherine Heigl) has a premonition that Denny (Jeffrey Dean Morgan), will not survive his heart-transplant surgery, while an OCD patient whose life is dictated by "the odds" drives Cristina (Sandra Oh) crazy. Elsewehere, Derek (Patrick Dempsey) and Addison (Kate Walsh) are still trying to work out their problems, with little success; Dr. Webber (James Pickens Jr.) treats his old friend Ollie (Mary Kay Place), and in the process relives a dark chapter in his own past; and George (T.R. Knight) is rapidly wearing out his welcome with Cristina and Burke (Isaiah Washington).