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Margaret Hayes plays the title character in From the Desk of Margaret Tyding. A successful businesswoman, Margaret has reason to believe that someone wants to do her ill. Her suspicions are confirmed when it is discovered that somebody has been slipping her small doses of poison. The chief suspects: Margaret's loving husband and trusted assistant. First telecast in color in the spring of 1958 on TV's Matinee Theater, the 60-minute From the Desk of Margaret Tyding later resurfaced in kinescope form as part of the syndicated series Cameo Theater.