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Max (Jessica Alba), Logan (Michael Weatherly), and Asha (Ashley Scott) try to track down the cause and cure for a Manticore virus that is sweeping Seattle. Herself infected, Max realizes that to continue her relationship with Logan would likely prove fatal to him; thus, she goes off with an old flame named Rafer (Kris Pope), a character introduced in the first-season episode "Meow." The outcome of the plot hinges on a "good samaritan" who is anything but.